Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the metabolic and immune status in a rat model

Abstrakt

The aim of the study was to evaluate the effects of a diet containing different levels of Cu in two differentchemical forms (carbonate and nanoparticles) on metabolic, immune and antioxidant status in a rat model. Fiveexperimental treatments (8 rats in each) were used to test different dosages of Cu added to the diet (standard−6.5 mg/kg, half the standard dosage−3.25 mg/kg, and no added Cu as a negative control) and two sources ofadded copper (standard−CuCO3and copper nanoparticles−CuNPs). Blood and urine samples were collectedfrom all the animals after four weeks of treatment. Metabolic and immune parameters were determined in bloodand urine samples. The study has shown that a dietary Cu deficiency (negative control) decreases rat’s plasmalevels of Cu, Fe, CREAT, BIL and IL-6, whereas reducing the level of Cu from the recommended 6.5 mg/kg to3.25 mg/kg decreases only the plasma concentration of TG, IgE and IL-6. Replacing CuCO3with CuNPs in ratdiets affects their metabolism, as indicated by decreased Ca, CREAT, BIL, ALB and IL-6 plasma levels. To sum up,CuNP added to a diet of rats have a more beneficial effect on metabolic indices (indicative of kidney and liverfunction) and inhibit inflammatory processes more effectively than CuCO3.

Autorzy

artykuł
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
Angielski
2018
48
111-117
20
2,895
16
24