The study focused on evaluation of the influence of moisture content of wheat (independent on wheat cultivar and screen mesh size) on grinding outcomes. Four Iraqi wheat cultivars, two hard Iraqi cultivars (Wahat Al-Iraq W1, Um Al-Rabeain W2 and two soft Iraqi cultivars (Abugraib W3 and Al-Forat W4) were used. Grinding experiments were carried out on a laboratory hammer mill at seven different moisture levels. i.e. 8, 10, 12, 14, 16, 18, and 20% (wet basis) and three screen mesh sizes: 1.0, 2.0 and 3.0 mm. The mill was equipped with a computer system to record grinding energy consumption. The Mastersizer 3000 (laser diffraction method) was used to estimate the mean particle size and surface specific of ground material. Higher values of energy consumption and mean particle size for hard wheat cultivars compared with soft wheat cultivars. When moisture content increased. The parameters of specific surface and grinding ability index had been decreased in condition of experiment. The statistical analyses showed clear differences for all grinding tests results while using the selected screen mesh sizes.