Applications of adductomics in chemically induced adverse outcomes and major emphasis on DNA adductomics: a pathbreaking tool in biomedical research

Abstrakt

Adductomics novel and emerging discipline in the toxicological research emphasizes on adducts formed by reactive chemical agents with biological molecules in living organisms. Development in analytical methods propelled the application and utility of adductomics in interdisciplinary sciences. This review endeavors to add a new dimension where comprehensive insights into diverse applications of adductomics in addressing some of society’s pressing challenges are provided. Also focuses on diverse applications of adductomics include: forecasting risk of chronic diseases triggered by reactive agents and predicting carcinogenesis induced by tobacco smoking; assessing chemical agents’ toxicity and supplementing genotoxicity studies; designing personalized medication and precision treatment in cancer chemotherapy; appraising environmental quality or extent of pollution using biological systems; crafting tools and techniques for diagnosis of diseases and detecting food contaminants; furnishing exposure profile of the individual to electrophiles; and assisting regulatory agencies in risk assessment of reactive chemical agents. Characterizing adducts that are present in extremely low concentrations is an exigent task and more over absence of dedicated database to identify adducts is further exacerbating the problem of adduct diagnosis. In addition, there is scope of improvement in sample preparation methods and data processing software and algorithms for accurate assessment of adducts.

Autorzy

Tapan Behl
Tapan Behl
Mahesh Rachamalla
Mahesh Rachamalla
Aayush Sehgal
Aayush Sehgal
Sukhbir Singh
Sukhbir Singh
Neelam Sharma
Neelam Sharma
Saurabh Bhatia
Saurabh Bhatia
Ahmed Al-Harrasi
Ahmed Al-Harrasi
Sridevi Chigurupati
Sridevi Chigurupati
Celia B. Vargas de la Cruz
Celia B. Vargas de la Cruz
Yahya H. Hobani
Yahya H. Hobani
Syam Mohan
Syam Mohan
Amit Goyal
Amit Goyal
Taruna Katyal
Taruna Katyal
Simona Bungau
Simona Bungau
artykuł
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Angielski
2021
22
10141
otwarte czasopismo
CC BY 4.0 Uznanie autorstwa 4.0
ostateczna wersja opublikowana
w momencie opublikowania
2021-09-20
140
6,208
0
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