Cytokines are low molecular weight signaling proteins which have a complex regulatory influence on inflammation and the immune system T-cells response. In response to various stimuli, cytokines are secreted by different cells predominantly white blood cells. Regulation of immune homeostasis requires a balance between sufficient cytokine produ hey integrate functions of several cell types into a coherent immune action to eliminate the pathogen and avoidance of a hyperinflammatory response. Pyroptosis, oncosis and necroptosis are inflammatory, lytic forms of programmed cell death that protect against infections and can be triggered by pathogen and host molecules. Inflammation, complex response involving immune cells, blood vessels, and molecular mediators, is part of innate defense mechanisms and plays a role in the healing process. Beyond the innate and adaptive immunity, cytokines has a major role in cytokine storm. No single definition of cytokine storm or the cytokine release syndrome, is widely accepted. Cytokine storm is based on the elevated circulating cytokine levels, acute systemic inflammatory reactions and dysfunction. Cases can progress rapidly to disseminated intravascular coagulation with either vascular occlusion or catastrophic hemorrhages, dyspnea, hypoxia, hypotension, hemostatic imbalance, vasodilatory shock, and death. In this article, interdependence of these inflammatory mediators in a normal and a dysregulated response was presented.