Lobularia libyca: Phytochemical profiling, antioxidant and antimicrobial activity using in vitro and in silico studies

Abstrakt

Lobularia libyca (L. libyca) is a traditional plant that is popular for its richness in phenolic compounds and flavonoids. The aim of this study was to comprehensively investigate the phytochemical profile by liquid chromatography, electrospray ionization and tandem mass spectrometry (LC-ESI-MS), the mineral contents and the biological properties of L. libyca methanol extract. L. libyca contains significant amounts of phenolic compounds and flavonoids. Thirteen compounds classified as flavonoids were identified. L. libyca is rich in nutrients such as Na, Fe and Ca. Moreover, the methanol extract of L. libyca showed significant antioxidant activity without cytotoxic activity on HCT116 cells (human colon cancer cell line) and HepG2 cells (human hepatoma), showing an inhibition zone of 13 mm in diameter. In silico studies showed that decanoic acid ethyl ester exhibited the best fit in β-lactamase and DNA gyrase active sites; meanwhile, oleic acid showed the best fit in reductase binding sites. Thus, it can be concluded that L. libyca can serve as a beneficial nutraceutical agent, owing to its significant antioxidant and antibacterial potential and due to its richness in iron, calcium and potassium, which are essential for maintaining a healthy lifestyle

Autorzy

Naima Benchikha
Naima Benchikha
Imane Chelalba
Imane Chelalba
Hanane Debbeche
Hanane Debbeche
Mohammed Messaoudi
Mohammed Messaoudi
Samir Begaa
Samir Begaa
Imane Larkem
Imane Larkem
Amara Djilani Ghamem
Amara Djilani Ghamem
Abdelkrim Rebiai
Abdelkrim Rebiai
Jesus Simal-Gandara
Jesus Simal-Gandara
Maria Atanassova
Maria Atanassova
Fadia S Youssef
Fadia S Youssef
artykuł
MOLECULES
Angielski
2022
27
12
otwarte czasopismo
CC BY 4.0 Uznanie autorstwa 4.0
ostateczna wersja opublikowana
w momencie opublikowania
2022-06-10
140
4,6
0
6