There are many accidents in road traffic involving both heavy goods vehicles and passenger vehicles, and the interpretation of the causes of some accidents can be very difficult. The paper presents the results of an analysis of the road accident causes involving a truck and two passenger cars. The hypothesis was verified that the incident took place after the damage to the front wheel of the truck, which resulted in an uncontrolled change of the direction of its travel and leaving the lane in the opposite direction of the passenger cars. The damaged tire was inspected, and traces were described in the form of cracks on the side surface, irregular abrasion on the central part of the side surface and near the bead, as well as deformations resulting from damage to the cord. The thesis was made that the tire cracked as a result of its material structure defects. In order to verify it, bench tests were carried out on the deformation of the tire sidewall at various load conditions, which simulated driving with too little air pressure in the tire. Detailed studies of the fracture of the tire sidewall and the wires that make up its steel cord were carried out. Macroscopic examination of the cord wires on eight samples revealed the presence of corrosion changes that should not occur under normal operating conditions. The results of the research work indicate that tire rupture was caused by delamination of the material coatings and corrosion of the steel cord wires. These defects could have arisen due to the earlier cracking of the rubber layer and the ingress of moisture or as a result of the use of corroded steel cord wires in tire production. In the analyzed case, the driver could not regain control of the vehicle and avoid a collision with oncoming vehicles.