Chitosan/Phenolic Compounds Scaffolds for Connective Tissue Regeneration

Abstrakt

Chitosan-based scaffolds modified by gallic acid, ferulic acid, and tannic acid were fabricated. The aim of the experiment was to compare the compatibility of scaffolds based on chitosan with gallic acid, ferulic acid, or tannic acid using the in vivo method. For this purpose, materials were implanted into rabbits in the middle of the latissimus dorsi muscle length. A scaffold based on unmodified chitosan was implanted by the same method as a control. Moreover, the Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR) spectra and scanning electron microscope (SEM) observations were made to study the interactions between chitosan and phenolic acids. Additionally, antioxidant properties and blood compatibility were investigated. The results showed that all studied materials were safe and non-toxic. However, chitosan scaffolds modified by gallic acid and tannic acid were resorbed faster and, as a result, tissues were organized faster than those modified by ferulic acid or unmodified.

Autorzy

Beata Kaczmarek-Szczepańska
Beata Kaczmarek-Szczepańska
Katarzyna Paździor-Czapula
Katarzyna Paździor-Czapula
Magdalena Gierszewska
Magdalena Gierszewska
Marta Michalska-Sionkowska
Marta Michalska-Sionkowska
Iwona Otrocka-Domagała
Iwona Otrocka-Domagała
artykuł
Journal of Functional Biomaterials
Angielski
2023
14
2
69
otwarte czasopismo
CC BY 4.0 Uznanie autorstwa 4.0
ostateczna wersja opublikowana
w momencie opublikowania
2023-01-28
100
5
0
2