Prenatal fumonisin exposure impairs bone development via disturbances in the OC/Leptin and RANKL/RANK/OPG systems in weaned rat offspring

Abstrakt

The goal of the current study was to examine the effects of prenatal exposure to fumonisins (FBs) on bone properties and metabolism in weaned rat offspring divided into groups intoxicated with FBs at either 0 (the 0 FB group), 60 (the 60 FB group), or 90 mg/kg b.w. 0 (the 90 FB group). Female and male offspring exposed to FBs at a dose of 60 mg/kg b.w. had heavier femora. Mechanical bone parameters changed in a sex and FBs dose-dependent manner. Growth hormone and osteoprotegerin decreased in both sexes, regardless of FBs dose. In males osteocalcin decreased, while receptor activator for nuclear factor kappa-Β ligand increased regardless of FBs dose; while in females changes were dose dependent. Leptin decreased in both male FBs-intoxicated groups, bone alkaline phosphatase decreased only in the 60 FB group. Matrix metalloproteinase-8 protein expression increased in both female FBs-intoxicated groups and decreased in male 90 FB group. Osteoprotegerin and tissue inhibitor of metalloproteinases 2 protein expression decreased in males, regardless of FBs dose, while nuclear factor kappa-Β ligand expression increased only in the 90 FB group. The disturbances in bone metabolic processes seemed to result from imbalances in the RANKL/RANK/OPG and the OC/leptin systems.

Autorzy

Rudyk Halyna
Rudyk Halyna
Monika Hułas-Stasiak
Monika Hułas-Stasiak
Maria Mielnik-Błaszczak
Maria Mielnik-Błaszczak
Donaldson Janine
Donaldson Janine
Piotr Dobrowolski
Piotr Dobrowolski
artykuł
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Angielski
2023
24
10
8743
otwarte czasopismo
CC BY 4.0 Uznanie autorstwa 4.0
ostateczna wersja opublikowana
w momencie opublikowania
2023-05-14
140
4,9
0
0