Polyphenols influence the development of endometrial cancer by modulating the gut microbiota

Abstrakt

Dysbiosis of the microbiota in the gastrointestinal tract can induce the development of gynaecological tumours, particularly in postmenopausal women, by causing DNA damage and alterations in metabolite metabolism. Dysbiosis also complicates cancer treatment by influencing the body’s immune response and disrupting the sensitivity to chemotherapy drugs. Therefore, it is crucial to maintain homeostasis in the gut microbiota through the effective use of food components that affect its structure. Recent studies have shown that polyphenols, which are likely to be the most important secondary metabolites produced by plants, exhibit prebiotic properties. They affect the structure of the gut microbiota and the synthesis of metabolites. In this review, we summarise the current state of knowledge, focusing on the impact of polyphenols on the development of gynaecological tumours, particularly endometrial cancer, and emphasising that polyphenol consumption leads to beneficial modifications in the structure of the gut microbiota.

Autorzy

Piotr Olcha
Piotr Olcha
Łukasz Nowakowski
Łukasz Nowakowski
Andrzej Miturski
Andrzej Miturski
Krzysztof Gałczyński
Krzysztof Gałczyński
artykuł
Nutrients
Angielski
2024
16
5
681
otwarte czasopismo
CC BY 4.0 Uznanie autorstwa 4.0
ostateczna wersja opublikowana
w momencie opublikowania
2024-02-28
140
4,8
0
0