Evaluation of the presence of gingivitis as confounding factor in assessing inflammatory status in serum and saliva of dogs with diabetes mellitus

Abstrakt

The aim of this study was to evaluate the changes in the serum and salivary inflammatory markers induced by Diabetes mellitus (DM) in dogs and to assess the possible confounding effect of gingivitis. A panel of 13 cytokines was measured in the serum and saliva of dogs diagnosed with DM and compared with healthy dogs without gingivitis (control group 1; CG1) and dogs with gingivitis but otherwise healthy (control group 2; CG2). The results of the present study showed statistically significantly higher levels of IL-8, KC-like and MCP1 in the serum of dogs with DM compared to CG1 dogs. In the case of saliva, the DM group presented statistically higher GM-CSF, IL6, IL15, and MCP1 levels compared to CG1, and lower KC-like chemokine compared to CG2. Finally, gingivitis produced changes in saliva, with salivary levels of GM-CSF, IL-6, IL-7, IL-15, IP-10, KC-like, IL-10, IL-18, MCP1, TNFα being statistically significantly higher in the saliva of CG2 dogs compared to CG1. The results of the present study indicate that dogs with DM have altered cytokine levels in serum and saliva compared to healthy dogs. In addition, this study highlights the importance of taking oral health into account when determining cytokines in dogs, as gingivitis can significantly alter their concentrations.

Autorzy

Franco-Martínez Lorena
Franco-Martínez Lorena
Munoz-Prieto Alberto
Munoz-Prieto Alberto
Busato Francesca
Busato Francesca
Karveliene Birute
Karveliene Birute
Stadaliene Inga
Stadaliene Inga
Ceron Jose J.
Ceron Jose J.
Carrillo Juana D.
Carrillo Juana D.
Garcia-Martinez Juan D.
Garcia-Martinez Juan D.
Pardo-Marin Luis
Pardo-Marin Luis
Martinez-Subiela Silvia
Martinez-Subiela Silvia
Tvarijonaviciute Asta
Tvarijonaviciute Asta
artykuł
BMC Veterinary Research
Angielski
2024
20
116
2024-03-23
140
2,3
0
0